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James Fraser, PhD


Image credit: © Steve Babuljak

Associate Director

Biophysics Graduate Program

Associate Professor

Department of Bioengineering and Therapeutic Sciences, UCSF Schools of Pharmacy and Medicine

Faculty affiliation

California Institute for Quantitative Biosciences (QB3) at UCSF


Fraser Lab

About my research

The long-term goals of our research are to understand how protein conformational ensembles are reshaped by perturbations and to quantify how these perturbations impact protein function and organismal fitness. We are best known for creating multitemperature X-ray data collection approaches, which are especially powerful when paired with multiconformer computational modeling to reveal otherwise inaccessible features of conformational ensembles. My group has also pioneered methods to model and evaluate the data emerging from the “resolution revolution” in cryo-electron microscopy.  We integrate high resolution EM, X-ray, NMR, and computation to improve protein engineering and small molecule discovery. In addition, I have incorporated new technologies in teaching, establishing a deep sequencing-based project course that published multiple papers with student co-authors and a new “Methods in Structural Biology” class, with EM, X-ray, and NMR data collection at UCSF or the Advanced Light Source at LBNL.


James Fraser, PhD
Associate Professor, Department of Bioengineering and Therapeutic Sciences
Associate Director, Biophysics Graduate Program
University of California, San Francisco (UCSF)
Genentech Hall MC2240
600 16th St Rm S472E
San Francisco CA 94158


Email: [email protected]

Tel: 415-502-1863